Sanjay Kalra
Bharti Research Institute of Diabetes & Endocrinology, India
Title: Medical nutritional supplement improves glycemic control in type 2 diabetes and prediabetes: A prospective study in Indian populationMedical nutritional supplement improves glycemic control in type 2 diabetes and prediabetes: A prospective study in Indian population
Biography
Biography: Sanjay Kalra
Abstract
Aim: To determine the long-term effect of Medical Nutrition Therapy (MNT) in adults with type 2 diabetes
(T2D) and prediabetes.
Background: T2D is one of the major non-communicable diseases with increasing prevalence at a global
level. Individuals with T2D are at high risk of developing cardiovascular and other life-threatening conditions.
Nutrient intake imbalances in diabetics are also frequently present due to food restrictions. Therefore, the
effect of MNT in diabetic and pre-diabetics is studied for 24 weeks.
Methods: This is a prospective observational study where MNT (VidavanceTM) is given for 24 weeks to
325 adult participants with T2D or prediabetes (HbA1c >6.0). Participants were either taking anti-diabetic
therapies along with MNT (n=156), or MNT alone (n=158). Glucose metabolism parameters and lipid profile
is assessed at baseline, 12 and 24 weeks.
Results: Total 313 participants completed the study. Statistically significant reduction in HbA1c levels is seen
from baseline to 12 weeks (8.6 to 7.7; p<0.001) and 24 weeks (8.6 to 7.1: p<0.001), due to only MNT. Similar
significant reduction in fasting glucose (167.4 to 119.4 mg/dL) and post-prandial glucose (232.1 to 156.2 mg/
dL) are observed at 24 weeks, due to only MNT. Significant reduction in levels of lipid profile parameters is
also seen. No adverse event is observed.
Discussion: Overall, MNT is found to be efficacious in reducing hyperglycemic parameters. HbA1c is
reduced by 0.9% at 12 weeks and by 1.5% at 24 weeks, due to only MNT. Significant reduction in fasting and
post-prandial glucose is also seen.