Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 2nd World Heart Rhythm Conference Dubai, UAE.

Day 2 :

Keynote Forum

Amr Alfakhouri

Lusatian Lakeland Klinikum GmbH, Germany

Keynote: Ablation strategies for atrial fibrillation

Time : 10:00-11:00

Conference Series Heart Rhythm 2019 International Conference Keynote Speaker Amr Alfakhouri photo
Biography:

Amr Alfakhouri, after qualifying as an Internist in Syria in 2011, he continued with his residencies in Germany and then became a specialist in Internal Medicine and Cardiology in 2017. He has gained experience in the field of Cardiac Electrophysiology and Device Therapy at the Heart and Vascular Day Hospital Dresden (Praxisklinik Herz und Gefäße Dresden), the Heart Centre Dresden and Heart Centre Cottbus. Currently he is employed as a Consultant Interventional Cardiologist and Electrophysiologist at Lausitzer Seenland Klinikum in Hoyerswerda, Germany. He also participated in the global research “CABANA and RDN-AF Enlight” at the Heart Centre Dresden.

 

Abstract:

Atrial fibrillation (AF) is the most common sustained arrhythmia. Recent guidelines recommend pulmonary vein isolation (PVI) as the main procedural endpoint to control recurrent AF in symptomatic patients resistant to antiarrhythmic drugs. The efficacy of such a procedure is still unsatisfactory in persistent AF. Thus, the search is on-going in trying to find adjunctive strategies that can fortify the durability of ablation success in AF patients. This review summarizes the benefits of AF ablation techniques, discusses the evidence underlying different approaches other than PVI including: linear ablation, ablation of complex fractionated atrial electro grams (CFAE), focal impulse and rotor modulation (FIRM), ablation guided by spatiotemporal electro gram dispersion, repetitive activation patterns (RAPs) and other sites frequently involved in AF triggers. It is interesting that other independent randomized studies (for example SMAN-AF and STAR AF II trails) have failed to reproduce the same successful results. The reason for the lack of benefit associated with additional ablation in these trials is unclear. A possible explanation is that more extensive ablation may cause new, iatrogenic areas of arrhythmogenesis. It is noted that the low success rate occurred even though the rate of acute procedural AF termination during CFAE ablation was high.

Conclusion: Future studies need to focus on new ablation strategies to achieve better results.

 

Keynote Forum

Geetendra Singh Dhanawat

Aditya Bharti Centre for Diabetes & Family Medicine, India

Keynote: Cinnamon and management of diabetes
Conference Series Heart Rhythm 2019 International Conference Keynote Speaker Geetendra Singh Dhanawat photo
Biography:

Geetendra Singh Dhanawat is an eminent diabetologist (Mumbai, India), completed his PG from CMC Vellore in Family medicine & MPH from
Global University. He is fellow of Royal society of Public health & Completed his Fellowship in intensive care medicine from Apollo Hospital.
He has special interest in diabetes and disease prevention. He completed PG Diabetology from John Hopkins University school of Medicine
& Dip. Diabetes from Stonebridge University, UK. He is a Consultant Diabetologist. He has published several papers in reputed journals
including Journal of WAO (World Allergy Organization). Member of Research society for study of Diabetes in India RSSDI.

Abstract:

Insulin sensitizing effect of Cinnamon: Miracle spice In our 14 month of clinical study the commonly used
Indian spice Cinnamon showed excellent results in prediabetic & newly diagnosed diabetic patients. In Our
clinical study we test the blood sugar lowering and insulin-sensitizing effects of Cinnamon (Cinnamomum
cassia). In our study we use 3gm of cinnamon in capsules to people with diabetes for 90 days. In 45 days
improvements in both fasting blood sugar and in LDL (“bad”) cholesterol evidenced. Although some clinical
trial results have been equivocal, several have shown benefits of cinnamon on glucose, lipid and insulin levels.
8-13 Studies also show cinnamon can potentiate insulin action and improve insulin resistance and glucose
metabolism although the detailed biochemical mechanisms aren't completely clear. Bioactive compounds in
cinnamon affect several steps in insulin signaling pathways. For example, research has shown that certain
water-soluble polyphenol compounds (type A polyphenols) extracted from cinnamon may increase insulin
sensitivity by inhibiting an enzyme (a tyrosine phosphatase) that inactivates insulin receptors.Other research
has found that water-soluble cinnamon polyphenols increase insulin-dependent proteins (GLUT4) required
for glucose uptake by adipose and muscle cells. Cinnamon extracts also may decrease proteins involved in
glucose production in the liver (gluconeogenesis). In addition, cinnamon compounds have antioxidant and
anti-inflammatory actions, which may play a role in reducing insulin resistance and diabetes complications.
The consumption of cinnamon is associated with a statistically significant decrease in levels of fasting plasma
glucose, total cholesterol, LDL-C, and triglyceride levels and an increase in HDL-C levels; however, no
significant effect on hemoglobin A1C was found. The high degree of heterogeneity may limit the ability to apply
these results to patient care, because the preferred dose and duration of therapy are unclear.

Conference Series Heart Rhythm 2019 International Conference Keynote Speaker Shumoos H Alwaid photo
Biography:

Shumoos H Alwaid has graduated with a bachelor degree of biology from College of Siences, completed her MSc at the age of 26 years
from Kufa University, College of Sciences and PhD studies from Kufa University, College of Sciences too. She is teaching human physiology
at The Islamic University, Collage of Medical Techniques. Her PhD thesis title was “Study the interrelation between some physiological and
immunological markers with diagnostic criteria of metabolic syndrome patients”.

Abstract:

Metabolic syndrome represents as a constellation of interconnected physiological, biochemical, clinical
and metabolic risk factors including hypertension, dyslipidemia, central obesity, glucose intolerance,
pro-inflammatory and pro-thrombotic states which reflects an underlying insulin resistance and cardio
vascular disease. Metabolic syndrome is a chronic low-grade inflammatory state starting from adipose
tissue and further recruits’ immune cells such as monocyte-macrophages. Adipose tissue has been suggested
to be a reservoir for inflammatory cells including monocytes which either migrate to or originate within
adipose tissue and release inflammatory bio mediators such as IL-6, TNFa etc. The aim of this study is to
find the correlation between inflammatory bio mediator IL-6 with the diagnostic criteria in obese metabolic
syndrome patients. A total of the (130) participants were divided into three study groups: women patients
group included 50 subjects, men patients group included 40 subjects the control group was 40 composed
of 20 healthy women and 20 healthy men. The ages of patients and control ranged 40 to 69 years old. Each
patients group was divided into subgroups according to age, BMI, WC. Lipid profile and blood sugar were
measured for all subjects. The results revealed significant increase in IL-6 level in serum of MetS patients in
compared with control group. While the result indicated there are no significant different in IL-6 between
MetS males and females. The study results also demonstrate, there is a significant positive correlation between
IL6 and TC, TG, LDL-C, BS levels in MetS patients.

Conference Series Heart Rhythm 2019 International Conference Keynote Speaker Juliot Vinolia photo
Biography:

Juliot Vinolia is a Dubai Health Authority licensed clinical dietitian and community nutritionist with over a decade experience in medical
nutrition therapy. As a research scholar, she received her M.Phil and Masters in Clinical Nutrition from the University of Madras, Women’s
Christian College, India. Heading the nutrition department at Medeor Hospital Dubai, she has provided personalized therapeutic nutrition care
for acute and chronically ill patients. She is also an active Columnist on national newspapers, magazines and corporate newsletters creating
awareness on the prevention of obestity related diseases like diabetes and cardiovascular diseases. Delivered lectures at conferences,
participated on radio talks and medical camps in creating healthier communities. She is affiliated with the American Society of Parenteral and
Enteral Nutrition, Indian Dietetic Association and Emirates Clinical Nutriton Society.

Abstract:

Cardiovascular disease (CVD) is a well known leading cause of mortality in Western countries, representing
almost 30 % of all deaths worldwide. With the rising incidence of heart disease among global statistics,
the American Heart Association and many other governmental organizations has taken it as a public health
priority in preventing CVD through diet and lifestyle interventions. Apart from the probability of developing
CVD from an unhealthy diet and lifestyle; CVD also coincides with multiple co-morbidities such as obesity,
hypertension, dyslipidemia and diabetes which represent four of the 10 greatest risk factors for all- cause
mortality worldwide. Current scientific evidence and many observational studies have reported that nutrition
might be the most preventive factor of CVD death and could even reverse heart disease. Several controversial
diets and foods have received significant media exposure and are mired by hype. The benefits of several
trending foods and dietary patterns like the ketogenic diet and fasting diets require more study period to
completely understand and nutritional science continues to evolve. The 2015 to 2020 Dietary Guidelines
for Americans recommend 3 healthy eating patterns: 1) the healthy US style eating pattern; 2) the healthy
Mediterranean and 3) the healthy vegetarian eating pattern. The latest guidelines emphasise on maintaining
a healthy weight through a healthy dietary pattern, active lifestyle, adequate sleep and stress management.
Individuals with pre-existing heart disease need individualized medical nutrition therapy taking into account
diabetes, hypertension and dyslipidemia management. As medical professionals our goal is to match the
intensity of preventive efforts with an individual's CVD risk and the individual's willingness and capacity to
implement preventive strategies.

Conference Series Heart Rhythm 2019 International Conference Keynote Speaker Ali Al Saeed photo
Biography:

Ali Al Saeed is a senior medical student at King Faisal University in Saudi Arabia. Ali is enthusiastic and passionate about science and
research. He got remarkable achievements locally including the prize of first place in the research day of college of medicine King Faisal
University. Ali has ongoing research project in different topics. Ali particularly is passionate about diabetes and metabolic disorders as they
are prevalent in the kingdom of Saudi Arabia. His interest in diabetes and obesity led him initiate “Anti childhood obesity community’’ in
the eastern province of Saudi Arabia, which is a cooperative project between King Faisal University and the United states in Riyadh. Ali is
member of many of nonprofit organization in KSA including Alber charity center, Hayat association and hereditary blood diseases and blood
donations associations in Al-Hassa

Abstract:

Diabetes mellitus has become the most common metabolic disease worldwide. The edible leaves of Red
cabbage (Brassica oleracea) are taken raw in salad or in the cooked form. Therefore, it was of interest to
evaluate the hypoglycemic and hypolipidemic effects of ethanolic (50%) extract of the leaves of red cabbage
to blood glucose, glycated hemoglobin (HbA1c) and lipid profile in streptozotocin (STZ)-induced diabetic
rats. Diabetes was induced in male Wistar rats by injecting rats with a single dose (60 mg/kg body weight) of
streptozotocin. Diabetic rats showed significant elevation in serum glucose, glycated hemoglobin (HbA1c)
total cholesterol (TC), and triacylglycerol (TG). Daily oral supplementation (250 mg/kg body weight) of
leaves of red cabbage extract for 40 days to STZ-induced diabetic rats significantly ameliorated serum glucose
(p < 001), HbA1c (p < 001), TC (p < 01), and TG (p < 01). By comparison, a standard anti-hyperglycemic
drug, glibenclamide when administered at a dose of 10 mg/kg body weight, reduced blood glucose, HbA1c,
TC and TGs levels. It is concluded that ethanolic extract of red cabbage reduced the blood level of glucose,
HbA1c and lipids and it was more effective than glibenclamide in reducing blood glucose.

Conference Series Heart Rhythm 2019 International Conference Keynote Speaker Sanjay Kalra photo
Biography:

Sanjay Kalra, an Endocrinologist, is the proprietor of Bharti Research Institute of Diabetes & Endocrinology (BRIDE), Karnal, Haryana.
His extensive professional journey of 14 years covers several stellar achievements in his field of specialty. He is instrumental in providing
editorial skills to several national and international medical journals focused on Endocrinology, Diabetes, Geriatrics, Family Practice, Medical
Research, Pharmacology, Hypertension and Nutrition. He is an Executive Editor of the Indian Journal of Endocrinology & Metabolism and
Editor-in-Chief of the International Journal of Clinical Cases & Investigations. He is the Vice President of South Asian Federation of Endocrine
Societies, since 2013.

Abstract:

Aim: To determine the long-term effect of Medical Nutrition Therapy (MNT) in adults with type 2 diabetes
(T2D) and prediabetes.
Background: T2D is one of the major non-communicable diseases with increasing prevalence at a global
level. Individuals with T2D are at high risk of developing cardiovascular and other life-threatening conditions.
Nutrient intake imbalances in diabetics are also frequently present due to food restrictions. Therefore, the
effect of MNT in diabetic and pre-diabetics is studied for 24 weeks.
Methods: This is a prospective observational study where MNT (VidavanceTM) is given for 24 weeks to
325 adult participants with T2D or prediabetes (HbA1c >6.0). Participants were either taking anti-diabetic
therapies along with MNT (n=156), or MNT alone (n=158). Glucose metabolism parameters and lipid profile
is assessed at baseline, 12 and 24 weeks.
Results: Total 313 participants completed the study. Statistically significant reduction in HbA1c levels is seen
from baseline to 12 weeks (8.6 to 7.7; p<0.001) and 24 weeks (8.6 to 7.1: p<0.001), due to only MNT. Similar
significant reduction in fasting glucose (167.4 to 119.4 mg/dL) and post-prandial glucose (232.1 to 156.2 mg/
dL) are observed at 24 weeks, due to only MNT. Significant reduction in levels of lipid profile parameters is
also seen. No adverse event is observed.
Discussion: Overall, MNT is found to be efficacious in reducing hyperglycemic parameters. HbA1c is
reduced by 0.9% at 12 weeks and by 1.5% at 24 weeks, due to only MNT. Significant reduction in fasting and
post-prandial glucose is also seen.

  • Complication and Preventions of Diabetes | Cardiology and Digital Health | Obesity and Cardiac Health | Diabetes Management | Hyperglycemia and Hypoglycemia

Session Introduction

Geetendra Singh Dhanawat

Aditya Bharti Centre for Diabetes & Family Medicine, India

Title: Cinnamon and management of diabetes
Speaker
Biography:

Geetendra Singh Dhanawat is an eminent diabetologist (Mumbai, India), completed his PG from CMC Vellore in Family medicine & MPH from Global University. He is fellow of Royal society of Public health & Completed his Fellowship in intensive care medicine from Apollo Hospital. He has special interest in diabetes and disease prevention. He completed PG Diabetology from John Hopkins University school of Medicine & Dip. Diabetes from Stonebridge University, UK. He is a Consultant Diabetologist. He has published several papers in reputed journals including Journal of WAO (World Allergy Organization). Member of Research society for study of Diabetes in India RSSDI.

 

Abstract:

Insulin sensitizing effect of Cinnamon: Miracle spice In our 14 month of clinical study the commonly used Indian spice Cinnamon showed excellent results in prediabetic & newly diagnosed diabetic patients. In Our clinical study we test the blood sugar lowering and insulin-sensitizing effects of Cinnamon (Cinnamomum cassia). In our study we use 3gm of cinnamon in capsules to people with diabetes for 90 days. In 45 days improvements in both fasting blood sugar and in LDL (“bad”) cholesterol evidenced. Although some clinical trial results have been equivocal, several have shown benefits of cinnamon on glucose, lipid and insulin levels. 8-13 Studies also show cinnamon can potentiate insulin action and improve insulin resistance and glucose metabolism although the detailed biochemical mechanisms aren't completely clear. Bioactive compounds in cinnamon affect several steps in insulin signaling pathways. For example, research has shown that certain water-soluble polyphenol compounds (type A polyphenols) extracted from cinnamon may increase insulin sensitivity by inhibiting an enzyme (a tyrosine phosphatase) that inactivates insulin receptors.Other research has found that water-soluble cinnamon polyphenols increase insulin-dependent proteins (GLUT4) required for glucose uptake by adipose and muscle cells. Cinnamon extracts also may decrease proteins involved in glucose production in the liver (gluconeogenesis). In addition, cinnamon compounds have antioxidant and anti-inflammatory actions, which may play a role in reducing insulin resistance and diabetes complications. The consumption of cinnamon is associated with a statistically significant decrease in levels of fasting plasma glucose, total cholesterol, LDL-C, and triglyceride levels and an increase in HDL-C levels; however, no significant effect on hemoglobin A1C was found. The high degree of heterogeneity may limit the ability to apply these results to patient care, because the preferred dose and duration of therapy are unclear.

 

Speaker
Biography:

Shumoos H Alwaid has graduated with a bachelor degree of biology from College of Siences, completed her MSc at the age of 26 years from Kufa University, College of Sciences and PhD studies from Kufa University, College of Sciences too. She is teaching human physiology at The Islamic University, Collage of Medical Techniques. Her PhD thesis title was “Study the interrelation between some physiological and immunological markers with diagnostic criteria of metabolic syndrome patients".

 

Abstract:

Metabolic syndrome represents as a constellation of interconnected physiological, biochemical, clinical and metabolic risk factors including hypertension, dyslipidemia, central obesity, glucose intolerance, pro-inflammatory and pro-thrombotic states which reflects an underlying insulin resistance and cardio vascular disease. Metabolic syndrome is a chronic low-grade inflammatory state starting from adipose tissue and further recruits’ immune cells such as monocyte-macrophages. Adipose tissue has been suggested to be a reservoir for inflammatory cells including monocytes which either migrate to or originate within adipose tissue and release inflammatory bio mediators such as IL-6, TNFa etc. The aim of this study is to find the correlation between inflammatory bio mediator IL-6 with the diagnostic criteria in obese metabolic syndrome patients. A total of the (130) participants were divided into three study groups: women patients group included 50 subjects, men patients group included 40 subjects the control group was 40 composed of 20 healthy women and 20 healthy men. The ages of patients and control ranged 40 to 69 years old. Each patients group was divided into subgroups according to age, BMI, WC. Lipid profile and blood sugar were measured for all subjects. The results revealed significant increase in IL-6 level in serum of MetS patients in compared with control group. While the result indicated there are no significant different in IL-6 between MetS males and females. The study results also demonstrate, there is a significant positive correlation between IL6 and TC, TG, LDL-C, BS levels in MetS patients.

 

Speaker
Biography:

Juliot Vinolia is a Dubai Health Authority licensed clinical dietitian and community nutritionist with over a decade experience in medical nutrition therapy. As a research scholar, she received her M.Phil and Masters in Clinical Nutrition from the University of Madras, Women’s Christian College, India. Heading the nutrition department at Medeor Hospital Dubai, she has provided personalized therapeutic nutrition care for acute and chronically ill patients. She is also an active Columnist on national newspapers, magazines and corporate newsletters creating awareness on the prevention of obestity related diseases like diabetes and cardiovascular diseases. Delivered lectures at conferences, participated on radio talks and medical camps in creating healthier communities. She is affiliated with the American Society of Parenteral and Enteral Nutrition, Indian Dietetic Association and Emirates Clinical Nutriton Society.

 

Abstract:

Cardiovascular disease (CVD) is a well known leading cause of mortality in Western countries, representing almost 30 % of all deaths worldwide. With the rising incidence of heart disease among global statistics, the American Heart Association and many other governmental organizations has taken it as a public health priority in preventing CVD through diet and lifestyle interventions. Apart from the probability of developing CVD from an unhealthy diet and lifestyle; CVD also coincides with multiple co-morbidities such as obesity, hypertension, dyslipidemia and diabetes which represent four of the 10 greatest risk factors for all- cause mortality worldwide. Current scientific evidence and many observational studies have reported that nutrition might be the most preventive factor of CVD death and could even reverse heart disease. Several controversial diets and foods have received significant media exposure and are mired by hype. The benefits of several trending foods and dietary patterns like the ketogenic diet and fasting diets require more study period to completely understand and nutritional science continues to evolve. The 2015 to 2020 Dietary Guidelines for Americans recommend 3 healthy eating patterns: 1) the healthy US style eating pattern; 2) the healthy Mediterranean and 3) the healthy vegetarian eating pattern. The latest guidelines emphasise on maintaining a healthy weight through a healthy dietary pattern, active lifestyle, adequate sleep and stress management. Individuals with pre-existing heart disease need individualized medical nutrition therapy taking into account diabetes, hypertension and dyslipidemia management. As medical professionals our goal is to match the intensity of preventive efforts with an individual's CVD risk and the individual's willingness and capacity to implement preventive strategies.

 

Speaker
Biography:

Ali Al Saeed is a senior medical student at King Faisal University in Saudi Arabia. Ali is enthusiastic and passionate about science and research. He got remarkable achievements locally including the prize of first place in the research day of college of medicine King Faisal University. Ali has ongoing research project in different topics. Ali particularly is passionate about diabetes and metabolic disorders as they are prevalent in the kingdom of Saudi Arabia. His interest in diabetes and obesity led him initiate “Anti childhood obesity community’’ in the eastern province of Saudi Arabia, which is a cooperative project between King Faisal University and the United states in Riyadh. Ali is member of many of nonprofit organization in KSA including Alber charity center, Hayat association and hereditary blood diseases and blood donations associations in Al-Hassa.

 

Abstract:

Diabetes mellitus has become the most common metabolic disease worldwide. The edible leaves of Red cabbage (Brassica oleracea) are taken raw in salad or in the cooked form. Therefore, it was of interest to evaluate the hypoglycemic and hypolipidemic effects of ethanolic (50%) extract of the leaves of red cabbage to blood glucose, glycated hemoglobin (HbA1c) and lipid profile in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced in male Wistar rats by injecting rats with a single dose (60 mg/kg body weight) of streptozotocin. Diabetic rats showed significant elevation in serum glucose, glycated hemoglobin (HbA1c) total cholesterol (TC), and triacylglycerol (TG). Daily oral supplementation (250 mg/kg body weight) of leaves of red cabbage extract for 40 days to STZ-induced diabetic rats significantly ameliorated serum glucose (p < 001), HbA1c (p < 001), TC (p < 01), and TG (p < 01). By comparison, a standard anti-hyperglycemic drug, glibenclamide when administered at a dose of 10 mg/kg body weight, reduced blood glucose, HbA1c, TC and TGs levels. It is concluded that ethanolic extract of red cabbage reduced the blood level of glucose, HbA1c and lipids and it was more effective than glibenclamide in reducing blood glucose.

 

Speaker
Biography:

Sanjay Kalra, an Endocrinologist, is the proprietor of Bharti Research Institute of Diabetes & Endocrinology (BRIDE), Karnal, Haryana. His extensive professional journey of 14 years covers several stellar achievements in his field of specialty. He is instrumental in providing editorial skills to several national and international medical journals focused on Endocrinology, Diabetes, Geriatrics, Family Practice, Medical Research, Pharmacology, Hypertension and Nutrition. He is an Executive Editor of the Indian Journal of Endocrinology & Metabolism and Editor-in-Chief of the International Journal of Clinical Cases & Investigations. He is the Vice President of South Asian Federation of Endocrine Societies, since 2013.

 

Abstract:

Aim: To determine the long-term effect of Medical Nutrition Therapy (MNT) in adults with type 2 diabetes (T2D) and prediabetes.

Background: T2D is one of the major non-communicable diseases with increasing prevalence at a global level. Individuals with T2D are at high risk of developing cardiovascular and other life-threatening conditions. Nutrient intake imbalances in diabetics are also frequently present due to food restrictions. Therefore, the effect of MNT in diabetic and pre-diabetics is studied for 24 weeks.

Methods: This is a prospective observational study where MNT (VidavanceTM) is given for 24 weeks to 325 adult participants with T2D or prediabetes (HbA1c >6.0). Participants were either taking anti-diabetic therapies along with MNT (n=156), or MNT alone (n=158). Glucose metabolism parameters and lipid profile is assessed at baseline, 12 and 24 weeks.

Results: Total 313 participants completed the study. Statistically significant reduction in HbA1c levels is seen from baseline to 12 weeks (8.6 to 7.7; p<0.001) and 24 weeks (8.6 to 7.1: p<0.001), due to only MNT. Similar significant reduction in fasting glucose (167.4 to 119.4 mg/dL) and post-prandial glucose (232.1 to 156.2 mg/ dL) are observed at 24 weeks, due to only MNT. Significant reduction in levels of lipid profile parameters is also seen. No adverse event is observed.

Discussion: Overall, MNT is found to be efficacious in reducing hyperglycemic parameters. HbA1c is reduced by 0.9% at 12 weeks and by 1.5% at 24 weeks, due to only MNT. Significant reduction in fasting and post-prandial glucose is also seen.